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Wouter Koek Selected Research

GABA-B Receptor Agonists

6/2007Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348.
6/2005Novel gamma-hydroxybutyric acid (GHB) analogs share some, but not all, of the behavioral effects of GHB and GABAB receptor agonists.
8/2003Continuous administration of the 5-hydroxytryptamine1A agonist (3-Chloro-4-fluoro-phenyl)-[4-fluoro-4-[[(5-methyl-pyridin-2-ylmethyl) -amino]-methyl]piperidin-1-yl]-methadone (F 13640) attenuates allodynia-like behavior in a rat model of trigeminal neuropathic pain.

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Wouter Koek Research Topics

Disease

10Catalepsy
09/2008 - 10/2002
8Pain (Aches)
07/2022 - 04/2003
8Body Weight (Weight, Body)
04/2014 - 06/2006
5Hypothermia
09/2016 - 08/2007
5Substance-Related Disorders (Drug Abuse)
03/2013 - 03/2007
5Hyperalgesia
03/2005 - 12/2002
4Ataxia (Dyssynergia)
04/2014 - 06/2005
4Narcolepsy
08/2008 - 01/2004
3Neuralgia (Stump Neuralgia)
07/2022 - 12/2002
3Spinal Cord Injuries (Spinal Cord Injury)
07/2022 - 10/2003
2Mental Disorders (Mental Disorder)
01/2019 - 01/2013
2Cocaine-Related Disorders (Cocaine Addiction)
08/2015 - 08/2012
2Central Nervous System Diseases (CNS Diseases)
05/2012 - 10/2010
2Mood Disorders (Mood Disorder)
06/2009 - 12/2008
2Feeding and Eating Disorders (Eating Disorder)
09/2008 - 03/2007
2Trigeminal Neuralgia (Tic Douloureux)
08/2003 - 12/2002
1Peripheral Nervous System Diseases (PNS Diseases)
07/2022
1Quadriplegia (Spastic Quadriplegia)
11/2021
1Paraplegia (Spastic Paraplegia)
11/2021
1Major Depressive Disorder (Major Depressive Disorders)
10/2020
1Insulin Resistance
01/2018
1Hypersensitivity (Allergy)
01/2017
1Postoperative Pain
01/2017
1Weight Loss (Weight Reduction)
03/2010
1Experimental Diabetes Mellitus
06/2009
1Neuroinflammatory Diseases
06/2009
1Disease Progression
06/2009
1Parkinson Disease (Parkinson's Disease)
06/2009
1Alcoholism (Alcohol Abuse)
12/2008

Drug/Important Bio-Agent (IBA)

6GABA-B ReceptorsIBA
03/2013 - 06/2005
6BaclofenFDA LinkGeneric
10/2010 - 12/2002
5Morphine (MS Contin)FDA LinkGeneric
04/2014 - 04/2003
5Serotonin (5 Hydroxytryptamine)IBA
01/2013 - 12/2008
5Pharmaceutical PreparationsIBA
08/2012 - 01/2004
5N-Methylaspartate (NMDA)IBA
08/2008 - 01/2004
5befiradolIBA
03/2005 - 12/2002
4Opioid Analgesics (Opioids)IBA
01/2017 - 04/2011
4Sodium Oxybate (gamma Hydroxybutyrate)FDA Link
08/2008 - 01/2004
4Dizocilpine Maleate (Dizocilpine)IBA
08/2008 - 01/2004
4Haloperidol (Haldol)FDA LinkGeneric
07/2007 - 10/2002
3Blood Glucose (Blood Sugar)IBA
01/2018 - 03/2007
3QuinpiroleIBA
12/2011 - 03/2007
3GABA-B Receptor AntagonistsIBA
10/2010 - 06/2005
3Amphetamine (Amfetamine)FDA LinkGeneric
09/2008 - 03/2007
3gamma-Aminobutyric Acid (GABA)IBA
08/2008 - 01/2004
3GABA-B Receptor AgonistsIBA
06/2007 - 08/2003
35-HT1A Serotonin ReceptorIBA
10/2003 - 10/2002
2Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA
10/2020 - 01/2013
2Cocaine (Cocaine HCl)IBA
08/2015 - 08/2012
2Serotonin ReceptorsIBA
01/2013 - 04/2011
2Dronabinol (THC)FDA LinkGeneric
12/2012 - 08/2007
2Cannabinoid Receptor AgonistsIBA
12/2012 - 06/2009
28-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)IBA
12/2011 - 06/2009
2RacloprideIBA
09/2008 - 03/2007
2Insulin (Novolin)FDA Link
09/2008 - 03/2007
2KetamineFDA LinkGeneric
08/2008 - 01/2004
2Streptozocin (Streptozotocin)FDA Link
02/2008 - 07/2005
2Antipsychotic Agents (Antipsychotics)IBA
07/2007 - 10/2002
23-aminopropyl(methyl)phosphinic acidIBA
06/2007 - 06/2005
24-hydroxybutyric acidIBA
03/2007 - 07/2005
2N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
07/2005 - 01/2004
1Capsaicin (Zostrix)FDA Link
07/2022
1SR-ATIBA
11/2021
1Starch (Cornstarch)IBA
11/2021
1IodineIBA
11/2021
1Cholinergic Antagonists (Anticholinergics)IBA
10/2021
1mirabegronIBA
10/2021
1Therapeutic UsesIBA
10/2020
1Ala(2)-MePhe(4)-Gly(5)- Enkephalin (DAGO)IBA
01/2017
1NicotineFDA Link
09/2016
11- (5- chloro- 2,4- dimethoxyphenyl)- 3- (5- methylisoxazol- 3- yl)ureaIBA
09/2016
1SugarsIBA
08/2015
1Sucrose (Saccharose)IBA
08/2015
1mu Opioid Receptors (mu Opioid Receptor)IBA
01/2013
15-HT2A Serotonin Receptor (5 HT2A Receptor)IBA
01/2013
1Opioid Receptors (Opioid Receptor)IBA
12/2012
13- chloro- 4- fluorophenyl- (4- fluoro- 4- (((5- methylpyrimidin- 2- ylmethyl)amino)methyl)piperidin- 1- yl)methanoneIBA
11/2010
1CorticosteroneIBA
11/2010
1(R,S)- 5,7- di- tert- butyl- 3- hydroxy- 3- trifluoromethyl- 3H- benzofuran- 2- oneIBA
10/2010
1AcidsIBA
10/2010
1Nitric Oxide Synthase (NO Synthase)IBA
10/2010
12,6- di- tert- butyl- 4- (3- hydroxy- 2,2- dimethylpropyl)phenolIBA
10/2010
1arginine methyl esterIBA
10/2010
1Naloxone (Narcan)FDA LinkGeneric
03/2010
1Clonidine (ST 155)FDA LinkGeneric
03/2010
1EscitalopramFDA Link
07/2009
1FenfluramineIBA
06/2009
1Fluoxetine (Prozac)FDA LinkGeneric
06/2009
1Brain-Derived Neurotrophic Factor (BDNF)IBA
06/2009
11- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
06/2009
1Dopamine (Intropin)FDA LinkGeneric
09/2008
1Dopamine AntagonistsIBA
09/2008
1Dopamine Agonists (Dopamine Agonist)IBA
09/2008
1Glucose (Dextrose)FDA LinkGeneric
09/2008
1Glutamate Receptors (Glutamate Receptor)IBA
08/2008

Therapy/Procedure

3Therapeutics
07/2022 - 01/2017
3Induced Hypothermia
10/2010 - 08/2007
3Analgesia
03/2005 - 12/2002
1Injections
01/2017
1Drug Therapy (Chemotherapy)
06/2009